Beta Glucuronidase High

An enzyme is a protein in the body that helps speed up important chemical reactions. Beta-glucuronidase is a crucial enzyme for detoxification of hormones, environmental toxins, and medications. However, high beta-glucuronidase levels can cause unwanted symptoms and hormone imbalances. 

In this article, we’ll explain the role of beta-glucuronidase, what high levels of this enzyme could mean for hormone and gut health, and potential functional medicine treatments.

Beta-glucuronidase is a very important enzyme produced naturally by certain intestinal bacteria and cells in your liver, intestines, and kidneys. This enzyme plays a crucial role in helping your liver detoxify excess hormones, environmental toxins, and certain medications. However, beta-glucuronidase is best known for its role in estrogen balance. 

In women, the body is constantly producing estrogen, although the levels should fluctuate throughout your menstrual cycle. Once estrogen has served its purpose, your liver uses beta-glucuronidase to bind glucuronic acid to estrogen so the body can eliminate it in the stool. In the intestines, beta-glucuronidase enzymes break the bond between estrogen and glucuronic acid, and the estrogen that was meant to be excreted is then reabsorbed into the bloodstream. However, under normal circumstances, the body will eliminate more estrogen than it reabsorbs.

However, if you have high beta-glucuronidase levels, your intestines may reabsorb too much estrogen back into the bloodstream. This can lead to symptoms of estrogen dominance.

Figure 1: Gut Health and Hormones (Estrogen Metabolism)

Because beta-glucuronidase is highly affected by gut health and the balance of gut bacteria, the primary intervention for reducing high levels of this enzyme is to treat the root causes of gut imbalance. 

High-meat, high-fat, and low-fiber diets are linked to higher beta-glucuronidase levels (1). However, a high-fiber diet rich in fruits, vegetables, nuts, seeds, and whole grains feeds the healthy bacteria in your gut and subsequently starves the bacteria that tend to cause high beta- glucuronidase. You should aim to eat at least 25-35  grams of fiber per day, spread out throughout each meal and snack. 

Make sure to also increase your water intake, as too much fiber without enough water can cause constipation. Besides feeding the right gut bacteria, the goal of increasing fiber intake is to also encourage daily bowel movements for adequate estrogen elimination. 

Dysbiosis and small intestinal bacterial overgrowth (SIBO) are common causes of high beta-glucuronidase. We can use the GI MAP stool test in our membership program to identify gut imbalances and develop a personalized gut healing protocol. In these scenarios, we may reduce bacterial overgrowth and dysbiosis with gentle (but effective) antimicrobial supplements like Microbiome Balance. 

After eliminating dysbiosis or bacterial overgrowth in the gut, consider supplementing with probiotics to further support gut health. Certain probiotics, like lactobacillus and bifidobacterium, can decrease beta-glucuronidase activity. We may suggest our Root Probiotic which contains seven of these useful strains. Fermented foods like yogurt, kefir, and sauerkraut are also excellent food-based sources of probiotics.

Bisphenol A (BPA) is a chemical used in various plastic products, like food storage containers, paper receipts, and plastic water bottles. Drinking out of plastic water bottles or eating leftovers out of plastic containers can increase beta-glucuronidase levels. This is because your liver clears this chemical through the same glucuronidation process as estrogen. 

While most products are listed as “BPA free” nowadays, manufacturers are simply replacing BPA with closely related chemicals, like bisphenol S. To reduce BPA or similar exposure, swap your plastic products for glass, stainless steel, or food grade silicone alternatives. Start with the items you use most, like your water bottle and coffee travel mug, and do not microwave your food in plastic containers. 

Citrus fruits, apples, and cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, cabbage etc.) provide glucaric acid to the body. This is a compound that is transformed in the stomach to a metabolite that inhibits beta-glucuronidase activity. Taking a supplement, like Calcium-D-Glucarate, may also provide this compound in higher concentrations to effectively reduce beta-glucuronidase (2).

Your liver has a natural process in place to detoxify excess hormones, toxins, medications, and more. However, various factors can sometimes interfere with the liver’s ability to effectively eliminate hormones, like estrogen. Supplements that support liver detoxification and glucuronidation can indirectly lower beta-glucuronidase activity. We may suggest milk thistle or resveratrol for liver support.