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Curing Histamine Intolerance

Are certain foods triggering your unwanted symptoms? 

Similar to allergies and food sensitivities, histamine intolerance may be another cause of your adverse food reactions. However, histamine intolerance is not well understood by most people and can be tricky to diagnosis.

In this article, we’ll explain this condition in simple terms and discuss if there is truly a method for curing histamine intolerance.

What is Histamine Intolerance?

Histamine is a chemical that has many functions in the body. It is found naturally in certain foods and is best known for its powerful actions during an allergic or inflammatory reaction. 

However, what is histamine intolerance? Despite the name, histamine intolerance is not an “intolerance” to histamine. Rather, histamine intolerance occurs when you have too much histamine than your body is able to effectively break down (1). 

The main enzyme in your body responsible for breaking down histamine is called diamine oxidase (DAO). 

Symptoms of Histamine Intolerance

While symptoms of histamine intolerance vary, some common reactions as a result of this condition may include (1):
symptoms of histamine intolerance
  • Headaches or migraines
  • Runny nose
  • Nasal congestion
  • Diarrhea
  • Asthma 
  • Low blood pressure
  • Hives and/or itching
  • Chronic fatigue
  • Irregular menstrual cycles
  • Anxiety
  • Dizziness

And many more! However, diagnosis of histamine intolerance is very tricky, which is why we use individualized functional medicine testing to get to the root cause of the issue (instead of relying solely on symptoms).

Causes of Histamine Intolerance

There are a few main reasons why someone may develop histamine intolerance.

Leaky Gut

In our practice, we often see histamine intolerance in conjunction with leaky gut. Since your intestines are where most of the DAO enzyme is produced, your body may produce less DAO when the gut is inflamed or damaged, thus leading to a build up of histamine. 

Healing the gut with diet, personalized testing, and using probiotics for histamine intolerance (when indicated) often leads to improvement. 


DAO is the main enzyme responsible for breaking down histamine from food sources. 

Some people may have an impaired ability to break down histamine due to a genetic polymorphism in the DAO gene. This means that your DAO gene may not effectively breakdown histamine as compared to individuals without the genetic mutation. 

If your DAO gene contains certain mutations (also known as “SNPs”), you may have an increased risk of developing histamine intolerance. Genetic testing can help determine if you have these mutations; however, a mutation in this gene doesn’t guarantee that you will have histamine intolerance.

You can purchase a DAO enzyme supplement here. 


Women tend to experience more histamine intolerance than men, which may be related to an imbalance of female sex hormones. 

In fact, female patients may experience worsening symptoms of histamine intolerance before or during their period. Some animal studies have shown that mast cells (which release histamine) within endometrial tissue are most significant during this premenstrual phase.  

Estrogen is also thought to activate histamine release from immune cells. So, if the amount of estrogen produced is much higher than the amount of progesterone—as seen in estrogen dominance—more histamine is released and may lead to worsening symptoms (2, 3).

We review the root causes of histamine intolerance in detail, as well as low histamine diets in our online course, Histamine Intolerance Healing. 
Histamine symptoms

Histamine Intolerance Healing

This course gives you access to information you won’t find anywhere else on what actually works for histamine intolerance. This is the ONLY histamine course taught by IFM certified doctors and dietitians with masters level nutrition training. This course includes: 6 weeks of video modules, guides, worksheets, a low histamine food plan and sample recipes.

What Foods Have Histamine?

While curing histamine intolerance requires a root cause, functional medicine approach, you may find some relief following a low-histamine diet. Eliminating foods that are high in histamine may reduce the amount of histamine in your bloodstream that your body has to eliminate.

Foods to avoid on a low-histamine diet:

  • Alcohol
  • Fermented foods, like kombucha, yogurt, and sauerkraut
  • Aged cheeses
  • Avocados
  • Dried fruit
  • Eggplant
  • Spinach 
  • Smoked meats
  • Shellfish
  • Tomatoes
  • Leftover food over a day old

Note: it is difficult for research studies to accurately measure the amount of histamine in all foods, so this is where a personalized elimination diet from a functional medicine dietitian can be very insightful. 

Curing Histamine Intolerance

While there is still question on whether one can cure histamine intolerance, you can definitely see improvement when you work on reducing inflammation and repairing a leaky gut. 

Effectively healing a leaky gut to improve histamine intolerance often requires removing food sensitivities, following a wholesome diet, reducing stress, and supplementing when necessary. 

Part of the gut health regimen for this condition may include probiotics for histamine intolerance. Probiotic supplementation may be used as many people with histamine intolerance cannot tolerate fermented foods (natural sources of probiotics).

Some probiotic strains may be helpful in reducing or breaking down histamine formation in the body. While research in this area is still new, some companies have created probiotics for histamine intolerance with these strains in mind. Our favorite probiotic is megaspore.

Other helpful supplements are DAO enzyme and D hist. 

DAO supplement

DAO enzyme

DAO is an MVP when it comes to breaking down food-derived histamine.
D hist


Our favorite supplement for seasonal allergy sufferers
histamine supplements

Histamine Bundle

Three of our favorite supplements that support histamine intolerance bundled together for savings.

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